In March 2016, Agar.io made an appearance in the Netflix show House Of Cards. This event increased both Agar.io and House of Cards' popularity. After this, a keyword skin named "Underwood" was added to the game.
In this episode (S4E9), Frank Underwood talks with another politician, Will Conway, about a game named Agar.io that his son likes to play. Conway tells Frank all about Agar.io and then starts playing. After he got eaten several times, he passes the smartphone to Frank. When Frank also got eaten a lot of times, Conway suggests that he use his real name in the nickname box so that players won't be so aggressive against him because they will know who they are competing. But still, Frank says :"I would rather enjoy the anonymity."
Then the scene ends.